Description Of The Mechanism Of Vasoreleaxant Effect Of Galic Acid Derivatives On The Contractoral Activity Of The Aortic Smooth Muscle
Keywords:
gallic acid derivatives, UDCA, TCA, oxidative stress, antioxidant activity, vasorelaxation, nitric oxide (NO), rat aorta, smooth muscle, ROS, cytoprotection.Abstract
In this study, the antioxidative stress effects of gallic acid derivatives — ursodeoxycholic acid (UDCA) and taurocholic acid (TCA) — were studied in rat aortic smooth muscle. As an experimental model, UDCA and TCA were added to aortic segments under phenylephrine-induced contraction, and their vasorelaxant properties and antioxidant mechanisms were evaluated. The results of the study showed that these substances significantly reduce ROS levels, enhance vascular relaxation, and that these effects are mediated by NO synthesis or calcium ion influx. In particular, the analysis of ROS levels using DHE confirmed the cytoprotective activity of these derivatives. These results substantiate the therapeutic potential of gallic acid derivatives in the cardiovascular system.
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