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The Effect Of Bile Acid Derivatives On Smooth Muscle Function Through Calcium Ion Channels

Authors

  • Shodiyakhon Solijonovna Sodiqova

    Lecturer, Kokand University
    Author

Abstract

In recent decades, the development of pharmaceutical and biomedical sciences has increasingly focused on the in-depth study of biologically active compounds, especially those derived from natural sources. This is due to the fact that naturally sourced substances often show better compatibility with the human body, lower toxicity, and broad-spectrum pharmacological activity. From this perspective, bile acids and their derivatives occupy an important place in pharmaceutical research.

References

Beuers, U., Trauner, M., Jansen, P., & Poupon, R. (2018). New paradigms in the treatment of cholestatic liver diseases. Hepatology, 67(1), 305-312.

Kim, Y. et al. (2018). Bile acids and nitric oxide production in endothelial cells. Vascular Pharmacology, 102, 23-29.

Park, S. et al. (2021). Synergistic effects of bile acid derivatives with calcium channel blockers. Korean Journal of Physiology & Pharmacology, 25(4), 445-452.

Sattarov, M. et al. (2020). Effect of bile acid derivatives on calcium channels in smooth muscles. Journal of Pharmacological Research, 45(2), 120-127.

Somlyo, A. P., & Somlyo, A. V. (2003). Ca²⁺ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiological Reviews, 83(4), 1325-1358.

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Published

2025-07-02

How to Cite

Sodiqova, S. S. (2025). The Effect Of Bile Acid Derivatives On Smooth Muscle Function Through Calcium Ion Channels. International Conference on Global Trends and Innovations in Multidisciplinary Research, 1(1), 12-16. https://tlepub.org/index.php/2/article/view/13