Antioxidant Activity And Stress-Protective Mechanisms Of Bile Acid Derivatives In Rat Aorta
Keywords:
bile acid derivatives, ursodeoxycholic acid, taurocholic acid, rat aorta, smooth muscle, vasorelaxation, nitric oxide synthesis, calcium channels, myography, antioxidant activityAbstract
This study investigates the effects of bile acid derivatives — ursodeoxycholic acid (UDCA) and taurocholic acid (TCA) — on the contractile activity of smooth muscles in the rat aorta. The research confirmed that both compounds induce dose-dependent vasorelaxation, and their mechanisms of action were analyzed in detail. The vasodilatory effect of UDCA was found to be associated with nitric oxide (NO) synthesis via the endothelium, while TCA’s effect was attributed to the restriction of calcium ion influx into cells. The sensitivity of phenylephrine-induced smooth muscle contraction to these substances was assessed using myographic methods. The results suggest that UDCA and TCA may serve as potential natural therapeutic agents for cardiovascular diseases.
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